and found no genetic associations with negative or positive subjective effects of alcohol. Finally, Arias and colleagues (2014), also using oral alcohol administration, found that subjects with one or two copies of the rs279858 C risk allele reported greater stimulation on the BAES, and higher “like alcohol”, “feel ‘high”, and “feel alcohol” on the Drug Effects Questionnaire, compared to subjects homozygous for the TT allele. Thus, while investigators frequently find that GABRA2 SNPs are associated with differences in subjective responses to alcohol, the reports are inconsistent; such contradictions might be due to variation in individual alcohol exposures after oral alcohol administration (Ramchandani et al., 1999), or to differences in type and number of scales used and when, how, and how often they were administered.
