Finally, we note that the four variants at PKNOX2, the four intergenic variants at MREG-PECR, GPD1L-CMTM8 and MAP3K9-PCNX, and the one variant at OPA3 had no significant eQTL signals in human brain and blood tissues in our analysis, and were not located at any TFBS/CNV/CpG/ESS, suggesting that they might play roles with less priority in risk for alcohol dependence than the preceding ADH cluster, SERINC2, KIAA0040, NRD1 and HTR7. Their biological functions in human remained to be validated.
