Chunk #21 — RESULTS — Disease associated HLA alleles underlie trans-associations to the MHC

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Genetics of gene expression in primary immune cells identifies cell type-specific master regulators and roles of HLA alleles.

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C.I. 1.30-1.54) the level of ARHGAP24 than all other alleles. These alleles are associated with autoimmune disease susceptibility, as is HLA-DRB4 (defining the DR53 antigen)39,40. Our study shows that specifically monocytes from individuals with HLA-DRB4 have significantly reduced AOAH expression, a protein with anti-inflammatory properties, in tandem with increased expression of ARHGAP24.