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Chunk #21 — SAMPLE QUALITY — Population substructure

Source
Quality control procedures for genome-wide association studies.
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yes

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Eigenstrat with iterative outlier removal, and reconciling these individuals with other ancestry information such as self-report could be used to identify a coherent set of ethnic outliers (which are identified as outliers and self-report as outliers) to potentially exclude from the analysis, rather than adjusting for many eigenvectors during the analysis only to retain a very small number of samples.