Chunk #28 — FROM GENE DISCOVERY TO POLYGENICITY: POLYGENIC AND WITHIN‐FAMILY APPROACHES TO ILLUMINATE MECHANISMS OF GENETIC RISK — Intergenerational transmission of AUD: Delineating the nature of nurture
While it is well‐established that genetic factors contribute to the familial aggregation of AUD, 4 , 133 questions remain about the mechanisms through which these genetic predispositions are passed from parents to children. Parents not only confer genetic risk to their offspring directly through allele sharing, but parental genotypes can also influence the types of home environments that children experience while growing up (i.e., an example of passive gene–environment correlation, or rGE 134 ). Critically, even the alleles that parents do not pass to their children (i.e., the nontransmitted alleles) can influence the family environment, and in turn children's outcomes, through what is known as genetic nurture. 119 , 120
