neurons that gave Eh1/2 values in the range −72 to −65 mV (Figure 5F) is consistent with increased expression of the Nav1.1 isoform in these cells. This isoform is preferentially expressed in GABAergic interneurons (Cheah et al., 2012; Han et al., 2012; Ogiwara et al., 2007; Yu et al., 2006) and the increased proportion of cells with this sodium channel phenotype is consistent with a greater proportion of GABAergic neurons in cortical organoids from probands with ASD.
