The large trans-ethnic meta-analysis of subjects of European and African descent carried out by the Psychiatric Genomics Consortium Substance Use Disorders working group (PGC-SUD) found that rs10516440 (associated with AD at p = 9.9×10−8; p conditioned on rs1229984 =7.4×10−5) was a significant eQTL for ADH1B in a trans-tissue analysis (p = 1.4×10−76, gtexportal.org), although only nominally significant in liver (Walters et al., 2018). The major allele of rs10516440 (A) was associated with increased ADH1B expression and reduced AD risk, concordant with the expected direction.
