protein level (Figure 2B). This dose-dependent pattern was completely reversed in heroin subjects with T/T subjects having the greatest level of HOMER1b/c protein level (P<0.01, Figure 2B). These effects were specific to the striatum since the DRD1 rs265973 was not significantly related to HOMER1b/c protein or mRNA expression levels measured in either the amygdala or cingulate cortex (data not shown). Also, toxicology did not affect protein expression as none of the heroin metabolites had a significant effect on HOMER1b/c expression.
