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Chunk #18 — Results — Simulation studies.

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Flexible statistical methods for estimating and testing effects in genomic studies with multiple conditions.
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Note that mash uses two distinct strategies to improve accuracy of effect estimates: (i) it shrinks estimates towards zero, which improves average accuracy because most effects are null; (ii) in the presence of “structured effects”, it shares information across conditions to improve accuracy. For example, if a unit has effects that are similar across a subset of conditions, averaging the effect estimates in those conditions will improve accuracy. Both these strategies contribute to the strong performance of mash in the “shared, structured” scenario.