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Chunk #7 — Materials and Methods — Sample

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Developmental trajectory and environmental moderation of the effect of ALDH2 polymorphism on alcohol use.
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Because the SNP variant (rs671) resulting in reduced ALDH2 enzymatic activity is almost exclusively found in East Asian populations, we genotyped only those SIBS participants of Korean descent, amounting to 356 participants. All participants had been adopted, with an average (SD) age at placement of .39 (.55) years. Phenotypic data were available for all 356 participants at IN and FU1 assessments, and 266 participants at FU2, because the second follow-up assessment is still ongoing. Age at IN was M(SD) = 14.81(1.81), at FU1: M(SD) = 18.13(1.99), and at FU2: M(SD) = 22.25(1.79). Of the genotyped participants, 59% were female.