of alcoholic drinks consumed in 24 hours (maxdrinks), reported many variants approaching the genome-wide threshold for suggestive significance (p < 5 × 10−5) (Heath et al. 2011). Bierut and coworkers (2012) used maxdrinks as a standalone measure of alcohol consumption and identified a SNP (rs1229984) in the ADH1B gene strongly associated with lower consumption of alcohol in populations of European and African ancestry. This SNP has been demonstrated to be functional and to have a strong impact on risk for alcoholism in all populations (Hurley and Edenberg 2012).
