The main contrast of interest (Alcohol versus Water) activated a broad set of regions including mesocorticolimbic areas such as the ventral striatum and ventrolateral frontal areas. Additional areas of activity were found in limbic cortex (insula, anterior and posterior cingulate gyrus/precuneus), superior parietal areas, medial frontal gyrus, medial prefrontal cortex, the thalamus, and occipital areas (Table 3, Figure 3). No significant activation was found for the complementary contrast (Water versus Alcohol). OPRM1 genotype (AG/GG versus AA) was found to moderate the activation within the Alcohol versus Water contrast such that G-allele carriers displayed greater activation within regions including the right insula, bilateral supramarginal gyri, left precuneus, right superior parietal lobule, right orbitofrontal cortex, and right angular gyrus associated with the presentation of the alcohol cue (Table 3, Figure 4).
