At the outset, multiple logistic regression analysis was performed on the combined sample of children of SUD+ and SUD− parents to determine whether transmissible risk, respectively, predicts age of alcohol use and cannabis use as well as AUD and CUD. Mediation analysis was conducted to determine whether age of onset of alcohol and cannabis is a marker of transmissible risk for AUD and CUD. Significance of mediated paths was tested using Sobel’s (1982) formula,
