No significant differences were observed between those with two ADH1C*1 alleles and those with at least one ADH1C*2 allele. Findings have been inconsistent regarding whether ADH1C polymorphisms influence alcohol dependence risk over and above the effect of ADH1B alleles (Luo et al., 2006; Osier et al., 1999). Some studies have identified modest differences between ADH1C*1 and ADH1C*2 in alcohol response (Duranceaux et al., 2006) and alcohol metabolism (Lee et al., 2006) after accounting for ADH1B status.
