of Cdk5.132 Induction of hippocampal deltaFosB by electroconvulsive treatments increases expression of hippocampal Cdk5 in rats.133 Cdk5 activity is primarily measured by assessing the phosphorylation of some of the many specific Cdk5 substrates, which include Ser-551 and Ser-553 of synapsin 1,134 multiple KSPXK sequences in the C-terminus of neurofilament-H,135 Thr-75 of DARPP-32,73 and several serine and threonine residues in the N- and C-termini of histone H1.136
