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Chunk #28 — Materials and Methods — Smoking-related diseases — Association analysis

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A rare missense mutation in CHRNA4 associates with smoking behavior and its consequences.
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Quantitative traits A generalized form of linear regression was used to test the correlation between the variants tested and quantitative traits (FTND and CPD) in Iceland. The generalized form assumes that the smoking behavior of related individuals is correlated proportional to the kinship between them rather than assuming that the smoking phenotypes of all individuals are independent.