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Chunk #27 — POTENTIAL EXPLANATIONS FOR SEX DIFFERENCES — Multifactorial polygenic model

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Using the tools of genetic epidemiology to understand sex differences in neuropsychiatric disorders.
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In summary, sex differences in the rate and presentation of psychiatric disorders reported in studies to date may be due to an artifact of reporting, sampling bias, or true male‐female differences in their incidence or prevalence. Sex differences may also be the result of differential impact of pre‐ or post‐natal environmental exposures, genetic effects arising from sex chromosome composition, or differing polygenic liability thresholds in males and females.