The potential impact of PRS in treatment response is unknown, but an easy first target is to test whether genetic disease susceptibility also plays a role in treatment outcome. Currently, the strongest evidence for a role of PRS in treatment response is in statin use to reduce the risk of first coronary event, where studies have shown that the relative risk reduction is higher in those at high genetic risk for cardiovascular disease [66, 67]. These results are in line with the previous reporting of better efficacy of statins in high-risk samples, for example, due to diabetes, hypertension, or high CRP concentrations [68]. A recent study demonstrated a potential role of PRS for electrocardiogram parameters in predicting the cardiac electrical response to sodium channel blockade [69].
