While the genetic association data pointed most strongly to rs1545843, gene expression and imaging data association were strong with both tag-SNPs of the locus, rs1545843 and rs1031681. In healthy subjects, genotype effects on hippocampal neurochemistry were more prominent for rs1031681 compared with rs1545843, both in terms of effects on NAA and Glx and in terms of robustness towards multiple test correction. This is an indication that both SNPs tag the likely underlying functional variants that still remains to be identified. To this aim deep-sequencing analyses are currently underway.
