In taking integration to the next level, PrediXcan [134] is a promising new gene-based method that utilizes genome-wide SNP genotypes and RNA-sequencing data in GTEx to build genetically regulated gene expression models in a diverse set of tissues and applying those models in GWAS with disease phenotypes of interest. The PrediXcan framework is applicable to other sources of ‘omics data (e.g., DNA methylation) in GTEx or elsewhere.
