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Chunk #39 — Bipolar Disorder

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CNVs: harbingers of a rare variant revolution in psychiatric genetics.
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Results from early CNV studies suggest that rare variants play a role in bipolar disorder (Malhotra et al., 2011; Priebe et al., 2011; Zhang et al., 2009a). However, the pattern that is emerging appears to differ somewhat from the patterns now evident in schizophrenia and ASD. Current evidence suggests that CNVs have a role to play (Malhotra et al., 2011), but some, particularly large deletions appear to play a very limited role (Grozeva et al., 2010; Malhotra et al., 2011).