Bloom et al. (2011) developed a metric based on several genetic variants in CYP2A6 to estimate nicotine metabolism. Cross-validation estimates that this metric predicts approximately 70% of the variance in metabolism of orally administered nicotine to cotinine in European Americans (Bloom et al., 2012). Our goal was to use this CYP2A6 metabolism metric to test whether CYP2A6 variation predicts cigarette smoking behaviors in young adulthood.
