subjects with a negative family history [43-46]. Although not all studies agree [47], a meta-analysis focusing on subjective level of intoxication confirmed a diminished response to alcohol as a characteristic more frequently seen in subjects with a positive family history than in those with a negative family history [48]. In addition, an 8-year follow-up of previously studied men with positive and negative family histories found that both a family history of alcoholism and a low response to alcohol were related to the development of alcohol-related problems [49].
