following chronic EtOH administration, altering the recognition and endocytosis of GABAA receptors by blocking AP-2 binding (Macdonald 1995; Mohler et al. 1996). A single dose of EtOH also increases the internalization of GABAA receptor α4 and δ subunits (Liang et al. 2007). In rat hippocampus, chronic EtOH exposure induces a decrease in the tyrosine kinase phosphorylation of α1 subunits, an increase of β2 subunits and no alteration in γ2 subunits (Marutha Ravindran et al. 2007).
