The SpiroMeta consortium consists of 14 GWAS studies: ALSPAC, B58C-T1DGC, B58C-WTCCC, EPIC (obese and population-based substudies), the EUROSPAN studies (Korcula, NSPHS, ORCADES and Vis), FTC (incorporating the FinnTwin16 and Finnish Twin Study on Aging), KORA S3, NFBC1966, SHIP and TwinsUK (see Table 1 for definitions of acronyms). The primary analyses on FEV1 and FEV1/FVC included 20,288 individuals of European descent. The measurements of FEV1 and FVC are described in the Supplementary Note.