The A disintegrin and metalloproteinase domain-containing protein 10 (ADAM10; chromosome 15) gene encodes the major brain alpha secretase. Alpha secretase cleavage can prevent Abeta formation and aggregation, and increase Abeta clearance. In vitro and in vivo studies have shown that two mutations (Gln171Gly and Arg181Gly) in the pre-domain region of ADAM10 may be associated with AD.170
