[5]–[15]. These effects are probably related to effects on the endocannabinoid system, which can modulate the neuronal activity of other neurotransmitter systems, such as dopamine, through its action on the most abundant cannabinoid receptor in brain, the cannabinoid receptor 1 (CB1) [16], [17]. CB1 receptors mature slowly, reaching maximal levels during adolescence [18], and are particularly concentrated in brain regions that are critical for executive functioning, reward processing and memory, such as the prefrontal cortex, anterior cingulate cortex, basal ganglia, medial temporal areas (e.g., hippocampus and amygdala) and cerebellum [19].
