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Chunk #12 — Materials and Methods — Statistical Analysis

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Associations and interactions between SNPs in the alcohol metabolizing genes and alcoholism phenotypes in European Americans.
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We corrected for multiple testing based on the number of independent association tests. To calculate this number, we used the method described in (Li and Ji, 2005). This method adjusts the number of independent tests based on the Eigenvalues of the N x N SNP correlation matrix. We then used a Bonferroni correction based on the number of independent association tests, also factoring in the correlation between the two phenotypes.