It’s also interesting to note, even in STIM trials that were at a similar PAC level to no-stimulation trials (by picking out PAC-matched trials with z-scored PAC between 0–0.4, P = 0.455, signed-rank test, Fig. 6A and B), clinical freezing was still significantly improved in these STIM trails as compared to no-stimulation trials (Fig. 6C–E). These results suggested that the freezing alleviation induced by STN-DBS was not due solely to the PAC reduction. Other modulation ways may also be in play here, such as elevating cortical resistance to excessive PAC.
