Few studies have reported the effects of ethanol on nAChRs in these areas. One study reported that co-administration of ethanol (i.p.) and nicotine infusions into the CA1 region or basolateral nucleus of the amygdala produced a significant conditioned place preference, while either drug alone did not; furthermore, this response was blocked by microinjection of mecamylamine into the CA1 or basolateral nucleus of the amygdala (Zarrindast et al., 2010). Taken together, nAChRs in the amygdala and hippocampus play a prominent role in not only learning and memory but also reward-related learning.
