could be measured via self-report or clinician diagnosis); 2) the genetic polymorphism and genetic model (e.g., additive) were the same as in the original study; 3) the environmental moderator was substantively the same; and 4) replication results were reported for the same gender as the original report. Because of the inherent subjectivity involved in determining whether environmental moderators such as “stressful life events,” “maltreatment,” and “hurricane exposure” should be considered equivalent, we deferred to the primary authors regarding whether specific environmental variables measured the same construct. When possible, we report whether the original finding was actually replicated (p<0.05 in the same direction) for a given study. For example, Brummett et al. (16) present significant results of a three-way interaction, but we used the clearly nonsignificant results of the two-way interaction that tested the original hypothesis (17). When we could not clearly discern whether the original study was replicated, the replication attempt was excluded. Replication attempts were excluded for the following reasons: genetic model discrepancies (nine studies), gender discrepancies (eight studies), insufficient information (two studies), and replication attempt within the original report (one study).
