proportion of heritability explained and the genotype score. With a heritability estimate of 30.4% in Framingham, these 14 loci explain a substantial proportion (~10%) of the inherited variation in FG. If these same loci harbor additional independent variants (e.g. those due to low frequency alleles not captured by this analysis) that also influence FG27, this estimate of the heritability attributable to these loci is likely to be conservative.
