Chunk #18 — Common and rare variants compared — Odds ratio distributions for common and rare variants

Source

Common and rare variants in multifactorial susceptibility to common diseases.

Embedded

yes

Text

The overall picture is already reasonably clear. Most common disease-associated variants will have ORs of at most up to 2, with many between 1.1 and 1.4, whereas many, if not most, rare variants will have ORs greater than 2, with a significant number considerably greater than 2.