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Chunk #44 — Discussion — Limitations

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The structure of genetic and environmental risk factors for syndromal and subsyndromal common DSM-IV axis I and all axis II disorders.
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Seventh, substantial attrition was observed from the original birth registry through three waves of contact. However, detailed analyses of the predictors of nonresponse across waves (26) revealed that cooperation was strongly predicted by sex, zygosity, age, and education but not psychiatric symptoms or self-report personality disorder items that have been shown empirically to predict DSM-IV personality disorder criteria in the personal interview phase. For example, among 45 predictors, including 22 mental health variables, only two—older age and monozygosity—predicted cooperation in the personal interview phase. Twin analyses of 25 mental health-related variables from earlier questionnaires reflecting psychiatric and personality disorder symptoms and substance use revealed no significant differences between those who completed a personal interview and those who did not (26). Thus it is unlikely that attrition introduced bias in the estimates of the etiological role of genetic and environmental risk factors for this broad range of mental health indicators. Our sample is probably broadly representative of the Norwegian population with respect to psychopathology.