The current study examined the associations between standard and extreme binge drinking and resting-state functional connectivity. Greater longitudinal standard bingeing was associated with a decrease in DMN-VAN connectivity from time 1 to time 2, controlling for the initial binge group memberships, longitudinal network changes, in-scanner movements, scanner effects, SES, sex, and age. Although most of the effects of longitudinal bingeing did not survive the FDR correction, networks involved in executive function (VAN, CO, Salience, FP) and memory (MTL) were the most often associated with binge drinking. We also conducted the consistency analysis that focused on edges whose change in connectivity strength significantly and consistently associated with bingeing. Although this analysis is exploratory, it allowed for retrieving the edge information that may be lost in the network-level analysis and extended the analysis to non-canonical addiction networks. The consistency analysis identified important seeds with a large number of edges that showed a consistent pattern of association with longitudinal bingeing. Indeed, when the whole-brain connectome was considered, both seeds in canonical addiction networks (VAN, DMN, CO) and non-canonical networks (Somatomotor Dorsal) were identified.
