exposure characterization to bring it up to par with genetic data. While recognizing that environmental exposures are not as static as genetic variants, part of this challenge may be addressed by developing low-cost approaches to do large scale assessment and characterization over time, including methods development and applications in longitudinal studies. There was discussion as to whether we should consider discovery studies for novel risk factors using exhaustive, systematic and agnostic analysis across multiple environmental factors [Patel, et al. 2013; Rappaport 2011], and discussion about the potential for including epigenetic components, such as non-coding RNA in GxE. An additional challenge was determining what methods were high priority in an environment of scarce resources.
