The same observation of the need of larger sample sizes applies to the analysis of HR loci identified within Europeans in other ancestries, where the lack of significance and concordance in the results from non-European populations is most likely due to a lack of power, as well as differences in the allele frequencies and LD patterns between Europeans and non-Europeans. As the non-European samples were much smaller, we did not perform a comprehensive comparison across populations or a robust trans-ethnic meta-analysis.
