cassette subfamily B member 1) is responsible for P-glycoprotein production. P-glycoprotein has been studied for its role in drug pharmacokintetics because it is present in endothelial cells of the blood-brain barrier which limits accumulation of its substates in the central nervous system. For example, P-glycoprotein deficient mice were reported to have significantly higher levels of the psychoactive component of marijuana, delta-9-tetrahydrocannabinol compared to wild-type mice (Bonhomme-Faivre, Benyamina, Reynaud, Farinotti, & Abbara, 2008).
