Because of smoking’s high co-morbidity with alcohol use (Meyerhoff et al., 2006) and the previous association between the ME3 gene and tobacco use (Vink et al., 2009), we used an unbalanced one way ANOVA to detect any associations between CNVs at chromosome 11 q14.2 and regular tobacco use. Of the 283 subjects included in this analysis, 149 subjects reported regular tobacco use. Here we define regular tobacco use as using tobacco at least once per day. No significant association, p < 0.05 was found between tobacco use and CNVs at chromosome 11 q14.2. However, our sample was significantly smaller (n = 283) than in the previous report (n = 1777) (Vink et al., 2009). This may account for the absence of association between CNVs at chromosome 11 q14.2 and tobacco use in our sample.
