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Chunk #20 — Methodology — Genetic correlations with external phenotypes

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Genetic association study of childhood aggression across raters, instruments, and age.
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A \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\chi ^2$$\end{document}χ2 difference test was applied to assess whether imposing the constraints resulted in a significant worse model fit compared to a model where the rgs between the phenotype and three rater-specific assessment of AGG were allowed to differ. We applied an FDR correction at α = 0.05 over two models for 46 external phenotypes, for a total of 92 tests. An FDR correction for 4 × 46 = 184 tests was applied to correct for multiple testing of whether the genetic correlations were significantly different from zero.