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Chunk #51 — Materials and Methods — Extraction of resting state timeseries

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Functional brain networks develop from a "local to distributed" organization.
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Resting state (fixation) data from 210 subjects (66 aged 7–9; 53 aged 10–15; 91 aged 19–31) were included in the analyses. For each subject at least 555 seconds (9.25 minutes) of resting state BOLD data were collected. 34 previously published regions comprising 4 functional networks (i.e., cingulo-opercular, fronto-parietal, cerebellar, and default networks; see Table 1 and Figure 1) were used in this analysis [16],[21],[22],[37]. For each region, a resting state timeseries was extracted separately for each individual. For 10 adult subjects, resting data was continuous. For the remaining 200 subjects, resting periods were extracted from between task periods in blocked or mixed blocked/event-related design studies [22]. These concatenated-extracted rest periods were shown to be equivalent to continuous resting data in a recent study describing this method [23]. In addition, several previous findings using this technique [21],[22],[32] have now been replicated using continuous resting blocks [27],[33],[34] and other continuous resting data [89].