Enrichment analyses were conducted separately for each factor score phenotype (Persistent Externalizing and six domain-specific factors) following the enrichment methods of Aliev and colleagues (2015) in their series of analyses. We first used PLINK to estimate the association between each individual SNP and the phenotype (factor scores), controlling for biological sex and genomic principal components (PC). We included only two of the top ten PC eigenvectors as covariates in these association analyses, as only these two were significantly correlated (p < 0.05) with any of the measures under examination (Turner et al., 2011). All analyses were conducted three times at three different significance thresholds for determining a SNP association hit, p = 0.05, 0.01, and 0.001 levels. An association with a p-value above a given significance threshold (e.g., p < .05) was considered a “hit.”
