Table 2 depicts the GEE results for the main effects of each alcohol response variable and their interaction with follow-up time. Results showed that heightened sensitivity to alcohol stimulation, liking, and wanting and lower sensitivity to sedation were significant predictors of AUD symptoms. Consistent with the modified differentiator model, at peak BrAC (60-minute net change score), higher alcohol stimulation and lower sedation predicted increases in AUD symptoms over time, but they were not significant predictors on either the rising and declining BrAC limbs after correction for multiple comparisons. In terms of incentive sensitization theory, both alcohol liking and wanting predicted more AUD symptoms but did not predict additional increases in symptoms through the 6 years (no significant interactions with follow-up time).
