A comprehensive portrait of genetic architecture does not now exist for any psychiatric disorder. Gaining more complete knowledge of the “parts list” for each disorder - the specific loci etiologically involved plus the identity, frequency, and impact of genetic variation at each locus - would be of exceptional importance. Such an enumeration would catalyze an array of specific, targeted and nuanced scientific studies. For example, such studies might lead to elucidation of biological mechanisms between the genotype and psychiatric phenotype, enablement of cell-based chemical biology and pharmacological screening, evaluation of gene action over developmental time, addressing the critical roles of gene-gene and gene-environment interactions, understanding the role played by epigenetic modifications, evaluation of disease prediction models, and so forth.
