Study that aims to examine how genetic risks unfold across development and in conjunction with the environment. Specifically, offspring in the extended families who were between ages 12–22 and had at least one parent who completed a SSAGA in the original COGA waves were recruited for the Prospective Sample (Bucholz et al., 2017). About 86% of the eligible offspring participated in the Prospective Study. These offspring participants completed a SSAGA, or an adolescent version of SSAGA (CSSAGA) if they were younger than 18 years old, at enrollment and were re-interviewed at approximately 2-year intervals. Prospective Study participants also completed questionnaires related to their environmental experiences including parenting behaviors. All COGA participants were asked to provide a DNA sample via blood or saliva. The Institutional Review Boards at all sites approved this study, and written consent (and assent for adolescents) was obtained from all participants. COGA data are available through the National Institute on Alcohol Abuse and Alcoholism or dbGaP (phs000763.v1.p1, phs000125.v1.p1).