CFC. Support for this hypothesis also comes from the observation that theta-burst transcranial magnetic stimulation (TMS) at the scalp is the most effective protocol for potentiating the motor cortical evoked potential [80]. These results, combined with the fact that CFC is modulated by centralized cholinergic control via the nucleus basalis [81] – a structure in the basal forebrain associated with plasticity and learning – supports a key role for CFC in learning. Given the strong correlation between CFC strength and learning performance, on the one hand, and learning and synaptic LTP/LTD, on the other, the hypothesis that phase-amplitude CFC provides a mechanism for regulating synaptic strength deserves further study.
