Chunk #12 — Materials and methods — Statistical analysis — Discovery sample

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Large-scale genome-wide association study of Asian population reveals genetic factors in FRMD4A and other loci influencing smoking initiation and nicotine dependence.

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Statistical analyses were performed using PLINK (Purcell et al. 2007) and R software. A logistic regression model was fit for the binary phenotype, SI-1, adjusting for age, sex, and geographic area under additive, dominant, and recessive models. The cumulative logit model was fit to the ordinal phenotype SI-2 and ND (Bender and Grouven 1997).