We used the Avon Longitudinal Study of Parents and Children (ALSPAC; Boyd et al., 2013; Fraser et al., 2013) to test for replication of individual variants as well as at the aggregate level. ALSPAC participants were born in 1991–1992 and are predominantly of European descent (>96%). The total ALSPAC sample included 15,247 pregnancies from women residing in Avon, UK with expected due dates between April 1991 and December 1992, resulting in 15,458 fetuses. Of this total sample, 14,775 were live births and 14,701 were alive at 1 year of age. The study website contains details of all the data that are available through a fully searchable data dictionary (http://www.bris.ac.uk/alspac/researchers/data-access/data-dictionary/). Ethical approval for the study was obtained from the ALSPAC Ethics and Law Committee, Bristol University and Virginia Commonwealth University. Genetic data are available for N = 8,237 individuals who meet quality control filters.
