PKA contributes to psychostimulant-induced locomotor sensitization. Intra-VTA injection of the PKA inhibitor Rp-cAMPS decreases amphetamine-induced locomotor sensitization. Sp-cAMPS, a PKA activator, increases amphetamine-induced locomotor sensitization in rats.105 Intracerebroventricular injection of forskolin, which increases PKA activity by increasing production of cAMP, enhances cocaine-induced locomotor sensitization in rats.106
