Cannabinoids have been shown to produce greater behavioral effects in female than in male rats (64, 65). There is also evidence showing that male Nrg1 HET mice being more sensitive to the acute effects of the psychotropic cannabis constitute Δ9-tetrahydrocannabinol (THC) which is not observed in females (66). We investigated whether there is a sex-specific effect for the rs17664708 in CaD susceptibility by sex-stratified analysis. We observed a stronger effect for rs17664708 in females (OR=3.08, 95% CI=1.56–6.07, P=0.0007) than in males (OR=1.88, 95% CI=0.95–3.74, P=0.055). The stronger effect of rs17664708 in females provides further evidence for the interactions between NRG1 and sex in CaD susceptibility.
